Methadone Pharmacology and Its Mechanism of Action

Methadone Pharmacology and Its Mechanism of Action Table of Contents (Jump to) 1. Goal 2. Aims and Objectives 3. Background 4. Methadone Pharmacology and Its Mechanism of Action 4.1 Methadone History Background 4.2 Benefits of Methadone 4.3 Deaths Involving Methadone 4.4 Pharmacokinetics and Metabolism of Methadone 4.4 Cytochrome P450 4.5 Cytochrome P450 Polymorphism and Adverse Drug Reactions 1. Goal Methadone is the most common and widely used drug for the opioid dependence in Ireland as in most of the countries in the E.U. Methadone treatment is undoubtedly effective however; the reports on methadone related mortalities have definitely stirred the public concern. The challenge for biotechnologists is to determine whether the application of pharmacogenomics can solve this dispute. The fact regarding any drug or opioid is that they affect different individuals in a different way. To solve this â€Å"Biological Puzzle† this case study links the role of methadone and CYP2D6 gene variations with the metaboliser status of individuals, which may serve as an adjunct in methadone related fatalities. CYP2D6 is a member of cytochrome P450 mixed oxidase system, which is involved in the metabolism of many toxicologically important drugs that commonly implicates in fatal poisoning. CYP2D6 gene is located on chromosome 22 and is highly polymorphic in nature. Single Nucleotide Polymorph ism (SNP) variation at the exon 4 position of the gene results in a single nucleotide change of G to A, which ensue in poor metabolism of the drug. This variation is amongst 5 to 10% of the Caucasian population. 2. Aims and Objectives The specific aims of this report are as follows: Describe the methadone pharmacology and its mechanism of action, which will include the pharmacokinetics and the pharmacodynamics of the drug. The role of cytochrome P450 in the metabolism of methadone. The focus will be on the genetic polymorphism and the adverse drug reaction. This research will further investigate on methadone’s safety profile and mortalities associated with the drug. 3. Background Methadone is a synthetic opioid, invented during the Second World War (White Torres, 2010). The first chemical synthesis of the drug was in 1939 at the pharmaceutical laboratories of I.G. Farbenkonzern, Germany. Methadone was introduced to the market during 1960’s and since then it is one of the most valued drug which has proved its effectiveness from the prevention of abstinence syndrome that occurs after rapid interruption of continuous opioid administration (Zweben Payte, 1990; Dole Nyswander, 1965). Methadone is also one of the most common medications administered for the treatment of heroin addiction, however; there are many fatal poisonings reported over the years (Bunten et al 2010). Methadone is a liposoluble basic drug, often administered orally as a racemic mixture of two enantiomers i.e. R-Met and S-Met (Garrido Troconiz, 2000). It has a long plasma elimination half-life that lies between 13 and 55 hours and a high bioavailability of 70% 90% when administered orally (Moffet et al, 2004). It is extensively metabolised in liver and is converted into its primary metabolite which is 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine (EDDP) (Crettol, Monnat Eap, 2007) and 2-ethyl-5-methyl-3,3-diphenyl-1-pyrroline (EMDP) (Lugo et al, 2005). Blood methadone concentration in drug tolerant individuals reaches >0.84 mg/l, whereas in cases of fatality or poisoning concentrations typically range from 0.4 mg/l to 1.8 mg/l. Fatalities have also been reported with concentrations as low as 0.05 mg/l which is significantly lower than the average concentration in blood (Caplehorn, Drummer Fatal, 2002). Studies suggests that the largest patient associated deaths are during t he drug induction phase, when either individual drug tolerance is overestimated or the presence of other drugs are also found in the system (Bunten et al 2010; CSAT, 2004). The revolutions in the molecular techniques in postgenomic era provide us a significant platform for the diagnostics and clinical purposes. Pharmacogenomics is the study of the impact of heritable traits on pharmacology and toxicology that acts as bridge to certify opioid fatalities (Wong et al 2002). The significant inter-individual variation in blood methadone concentrations and individual susceptibility to methadone toxicity might be explained through genetic variations of the genes encoding the drug metabolism enzymes. Pharmacogenomics acts as the linkage between an individual’s genotype and individual’s ability to metabolise a foreign compound (Linder, Prough Valdes 1997). Most xenobiotics, including therapeutic drugs, are metabolised by cytochromes P450 to some extent (Guengerich, 2006). The metabolism of these drugs results in detoxification and elimination of drug or activation of the prodrug to its biologically active form. Cytochrome P450 (CYP450) shows a wide interindividual variation in their protein expression and/or catalytic activity, which results in unique drug metabolism (Jannetto et al 2002). Among the P450 subfamilies, CYP2D6 plays a critical role in determining the response to several drug groups/families (Sadee 1999). CYP2D6 gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are mono-oxygenases, consisting of more than 30 enzymes (Schur et al 2001) which catalyze many reactions involved in drug metabolism. This protein localizes to the endoplasmic reticulum and is known to metabolise as many as 20% of commonly prescribed drugs. CYP2D6 gene substrates include debrisoquine (Wennerholm et al, 1999) an adrenergic-blocking drug; sparteine and propafenone, both anti-arrythmic drugs; and amitryptiline, an anti-depressant. CYP2D6 gene is highly polymorphic in population (Neafsey et al, 2009); certain alleles result in the poor metaboliser phenotype, characterized by a decreased ability to metabolise the enzymes substrates. The polymorphism is due to multiple mutations of the gene, which result in absent, functionally deficient, under-expressed or over-expressed protein (Shiran et al, 2003). The gene is located near two cytochrome P450 pseudogenes on chromosome 22q13.1 (Gouch et al, 1993). Alternatively spliced transcript variants encoding different isoforms have been found for this gene (Toscano et al, 2006). CYP2D6 is a polypeptide of 497 amino acids that accounts for only small a percentage of all hepatic P450s but its role in drug metabolism is extensively higher than its relative content (Zanger et al, 2010). 4. Methadone Pharmacology and Its Mechanism of Action 4.1Methadone History Background Methadone was introduced to the market in 1960’s (Serban, 2011; Liebrenz et al, 2010). The drug was approved by the Food and Drug Administration (FDA) in 1947 as an analgesic; by 1950 it was used for the treatment of painful symptoms from heroin withdrawal and other opioids (SAMSHA, 2004). In 1964, researchers discovered that continuous, daily maintenance doses of oral methadone allowed opioid-addicted patients to function more normally in the process of their recovery (Payte, 1991; Zweben and Payte, 1990; Dole, 1988; Gearing and Schweitzer, 1974). Fig: 2 Methadone Chemical Structure Methadone in the modern medicine is used both as an analgesic for severe pain relief as well as in the treatment of opioid dependence (Rowley, 2011; Potter, 2010). Many scientific articles reviewed methadone to be the currently preferred drug of choice for the treatment of opioid dependence in many countries, including the U.K. (Nosyk et al, 2010; Verster and Buning, 2000). Fredheim et al, (2008) in their review reported that currently, methadone has had a renaissance in the treatment of pain because it has proven its usefulness as a second line drug in opioid switching when other opioids fail to show their effectiveness. Methadone has also been found to be the valued medication for its effectiveness in reducing the number of deaths associated with opioid addiction as well as various medical and behavioural prevalence of diseases associated with addictive disorders (Maxwell, Pullum Tannert 2005; Sheilds et al. 2007). However, the news headlines of many prominent newspapers including the New York Times and the Washington Times, in 2002 and 2003 hyped its publicity by reporting the opioid medications were the major cause of deaths in drug abuse treatment (Belluck, 2003a, 2003b, 2003c; Associated Press, 2002; Washington Times, 2003). New York Times even mentioned methadone as a â€Å"Killer Drug† which is widely abused and dangerous (Washington Times, 2003). After these issues it was decided by the U.N. to put methadone in the class of controlled drug. Methadone was declared in a controlled drug category by the United Nations convention and placed under the controlled substances (â€Å"narcotics†) by the Single Convention on Narcotic Drugs, 1961 (Single Convention) (Bosnjak et al,2011). However, it can only be prescribed in the UK, as in most countries, by prescription till present (Verster Buning, 2000; CSAT 200b). 4.2 Benefits of Methadone Methadone is one of the most preferred drugs not only in Ireland but also across several continents around the globe. In the report published by European Monitoring Centre for Drugs and Drug Addition (EMCDDA), there is a seven fold increase in the opioid treatment between 19993 -2000. The drug is widely recognised amongst doctors and patients due to its several socio-economic reasons. It is observed that there is a significant decrease in the crime graph and a noticeable increase in the employment services amongst the patients undergoing methadone maintenance treatment. No doubt, there is a reduction in illicit drug use by the opiate users and increase in social integration is one of the benefits of methadone. In addition, methadone also helps in reducing morbidity and mortality among opiate users. 4.3 Deaths Involving Methadone Methadone is a highly potent drug for the treatment of opioid dependence and acts as an analgesic for second line management of chronic pain. However, increase in mortality due to methadone administration has instigated controversies regarding the drug use (Lowe, Brooks Petry, 2010; Bunten et al 2010). Law enforcement agencies in the United States (U.S.) and the Drug abuse Warning Network (DAWN) ranked methadone as the third most apprehended analgesic used in the treatment of pain management, fourth among all controlled pharmaceuticals, and eighth among all controlled substances (Fig:2.1.1) (SAMSHA, 2007). Various researches conducted amongst patients undergoing addiction treatment shows that the majority of methadone related deaths occur during the drug induction phase. Post-mortem sample predicts either an overestimation of the drug or combined usage of various other central nervous system (CNS) depressant in addition to the prescribed methadone (Bunten et al, 2010; Lowe, Johnson Petry, 2007). Fig: Methadone as the third most apprehended analgesic, fourth among all controlled pharmaceuticals, and eighth among all controlled substances (SAMASHA, 2007) The side effects associated with methadone overdose includes nausea, vomiting, dizziness, clouding of consciousness and pruritus (itching) (Davis Walsh, 2001). However, the primary toxic effect of excessive methadone is respiratory depression and hypoxia, sometimes accompanied by pulmonary edema and/or aspiration pneumonia (White and Irvine, 1999; Harding-Pink, 1993). Methadone related deaths during later phases of the additiction treatment mainly signify the presence of other illicit drugs. Researchers generally use the term â€Å"poison cocktail† describing the fatality due to intake of multiple psychotropic drugs (Borron, et al., 2001) such as alcohol, benzodiazepines, and other opioids. Several opioids when used or prescribed alone are relatively moderate respiratory depressants; however, when combined with methadone, their additive or synergistic effects can be lethal (Kramer, 2003; Payte and Zweben, 1998). Safety Information and Adverse Event Reporting Program a subsidiary of Food and Drug Administration (FDA) confirms 1,114 cases of methadone-associated fatalities in adults from 1970 through 2002. Critically, a greater number of deaths were reported in 2001 alone than during the entire period from1990 through 1999; the number doubled itself in 2002. In the U.K. 225 individuals died whilst undergoing methadone treatment in 1993. In 1997, data confirms 449 deaths due to the same cause. However, the mortality graph went down in 2001 by reporting 279 deaths caused by methadone but in 2002, it again rose to 316. Therefore, we can conclude that there is no regular trend in methadone related deaths. However, Corkery et al (2004), mentions that it is always not necessary for methadone to be the cause of death even according to the death certificate of the individuals. In an individual study, methadone was detected in the post-mortem blood of 352 unexplained sudden deaths in Scotland between 1 991 and 2001. 23 % of these deaths were not directly linked with methadone. However, there were other drugs and/or alcohol found in the blood sample of the individuals. The Substance Abuse and Mental Health Services (CSAT) in 2004 states that all methadone related poisoning eventually leads to cardio-toxicity and respiratory depression. Methadone deaths expressed as Percent of all poisoning deaths (CSAT, 2007). United States Poison Control Centres states that the overall number of opioid-related deaths has been on the rise, with many cases involving other opioids that include oxycodone and hydrocodone (Litovitz, et al., 2002; Florida Department of Law Enforcement, 2002) 4.4 Pharmacokinetics and Metabolism of Methadone Methadone is a liposoluble basic drug with a pKa of 9.2 and is usually administered orally as a recemic mixture of two enantiomers: R-methadone (R-Met) and S-methadone (S-Met) (Fig.2.2) (Trescot, 2010). The plasma half-life of the drug is highly variable and is between 13 and 55 hours but it is usually assumed to be an average of 25 hours (Letsky et al, 2011; Albion et al, 2010; Wolff et al, 2002). The bioavailability is 70% to 90% when administered orally (Bunten et al, 2010; Lowe, Brooks Petry, 2010). Studies indicate that in drug naive individuals, a single dose of methadone can show its clinical effects up to 72 hours in duration (Olsen et al, 1997). However, the peak plasma concentration reaches in 2 to 4 hours. The analgesic effect of the drug sets in about 15 minute after the subcutaneous injection (Eap et al, 2002). The chemical structure of r-(-)-methadone and s-(+)-methadone (asterisk (*) denotes chiral centre). There is a wide distribution of methadone amongst tissues, which generally range from 60 to 90%. As a result, the drug shows slow elimination and cumulative effect. Methadone is mostly metabolised in liver. The primary metabolite of the drug is 2-ethylidene-1, 5- dimethyl-3, 3-diphenylpyrrolidine (EDDP) (Fig) (Bunten et al, 2010) and to some extent 3, 3-diphenyl-1-pyrroline (EMDP) (Corkery et al, 2004). However, both of these metabolites are inactive and elimination of these inactive metabolies is through urine and faeces. Anggard and Inturrisi et al. (1975) (1990) mentioned that as a result of the basic (pKa =9.2) and lipophylic properties, methadone undergoes a hepatic metabolism and renal excretion. Fig: 4 Metabolic Conversion of Methadone to EDDP 4.4 Cytochrome P450 Cytochrome P450 (P450) is a large superfamily of enzymes. The origin of P450’s superfamily is since prokaryotes much before the existence of eukaryotes (Omura, 2010). The gene P450, commonly known as â€Å"CYP† is present in the genomes of virtually all organisms. Moreover, studies suggest that heme proteins are the building blocks of CYP450 enzymes. These enzymes play a crucial role in the metabolism of the various xenobiotics, steroids and other chemicals. Most of the drugs and chemicals are lipophilic to become more water soluble before excretion. Therefore, P450 superfamily of hemoproteins serves as terminal oxidases of the mixed function oxidase system (Wrighton and Stevens, 1992). The heme prosthetic group binds oxygen after electron transfer reactions from the reduced form of 24 nicotinamide adenine dinucleotide phosphate (NADPH). This reaction incorporates a single atom of molecular oxygen into a substrate with the concomitant reduction of the other atom to wate r (Synder, 2000; Omura, 1999). In cytochrome P450, ‘P’ denotes the pigment and the number ‘450’ is the spectral properties for the absorption band at 450 nm of the reduced CO-bound complex (Benhardt, 2006; Reichhart Feyereisen, 2000). However, according to the nomenclature society, the term â€Å"CYP† is followed by number of families which are generally group of proteins with more than 40% amino-acid sequence identity, a letter for subfamilies and a number for the gene e.g. – CYP2D6. Studies indicate that P450 superfamily is highly diverse (Mathew, 2010). Diversity of P450’s is mainly due to the extensive process of gene duplications. However, gene amplifications, conversions, genome duplications, gene loss, and lateral transfers are certain scenarios that are less documented. 4.5 Cytochrome P450 Polymorphism and Adverse Drug Reactions Drugs affect different individuals in a different way. Genetic variations, which affect the response of the drug metabolism, can be of the most probable reasons (Mayer Zanger, 1997). Johansson Sunderberg (2010) also reported that the difference in drug metabolism among individuals might be due to several factors e.g. epigenetic, pathophysiological, or it might be due to some environmental factors. In a population, genetic polymorphism is divided according to individual ability to perform drug transformation reaction (Srivastava, 2003). Moreover, polymorphic trait is also noticed due to certain mutation in the genes and/or a single nucleotide polymorphism (SNP) which results in the enzyme variation and leads towards higher or lower activity. As a result, there is a partial or complete absence of an enzyme protein in the system. (FIG:) Fig: Polymorphism of Drug Metabolism Enzymes (Evans Relling, 1999). As we can see from the above figure that the genetic polymorphism applies for a wide range of drugs and xenobiotic metabolizing enzymes. Identification of these variations were by the occurrence of adverse reactions after normal doses of drugs in patients or volunteers. In adverse drug reactions, drug-drug interactions have its key role. In fact, adverse drug reactions (ADRs) are one of the major causes of death which is reported in many scientific articles, reviews and even government scripts. According to Substance Abuse and Mental Health Administration (SAMSHA) (2007), there is a record of approximately 100,000 deaths in the United States due to drug toxicity. In addition, Eichelbaum et al., (2006) stated that ADRs is also responsible for up to 7% of hospitalizations and the number has increased to > 30% in the elderly population (> 70 years of age) (Paul et al., 2008). ADRs mainly affect cardiac function or cause liver toxicity (Need et al., 2005). The CYP families metabolises approximately, 75% of all clinically used drugs (Bertz and Granneman, 1997; Evans and Relling, 1999).The human genome contains 115 CYP genes, out of which 57 are found to be functional and the rest are reported as pseudogenes (Johansson Sundberg, 2010; Wang et al,2003). Among CYP families, there are 22 different P450 isoforms, which shows a high degree of polymorphism. Therefore, we can divide the polymorphic xenobiotic metabolizing CYP enzymes into two classes according to their interindividual susceptibility for xenobiotics: Class I: Composed of CYP1A1, CYP1A2, CYP2E1, and CYP3A4 without important functional polymorphism and active in metabolism of drugs. Class II: Composed of CYP2A6, CYP2B6, CYP2C9, CYP2C19, and CYP2D6, which are highly polymorphic and are important for the metabolism of drugs.

Understanding The Yellow Wallpaper -- Yellow Wallpaper essays

Understanding The Yellow Wallpaper      Ã‚   There are more reported cases of clinical depression in women than their are in men. There is also, generalized in western cultures, a stereotype that women are fragile and should be more dedicated to maintaining the home, doing feminine things, that they shouldn't work, and be discouraged from intellectual thinking. In the Victorian period (1837-1901) aside from women's suffragette movements the Victorian woman usually upheld this stereotype of a well behaved wife, more or less a possession then an individual. However, there were a few who defied the odds and took it to heart to let the world know about the indifference's that they went through. Charlotte Perkins Gilman, feminist, was one of these women who used her writing to express the differences and hardships women went through. One of her more famous works, the Yellow Wallpaper, is known as both a feminist piece and a depiction of Victorian life and indifferences for women. It is a piece that can have controversial me anings that can be taken to heart to why Gilman ever wrote it.    "The Yellow Wallpaper" has a simple enough story, the woman is taken to a rented house to recover from a nervous depression that she was experiencing. The depression was something common in women of the time, especially in more upper class women with little to do. The antidote " the cure" was developed by a Weir Mitchell, for psychoneurosies, in theory a women should inhibit herself from any kind of work or thinking and to get as much fresh air as possible. The heroine is subjected to this cure. Having been confined to a room in the house she starts imagining things in the wallpaper that she hates so much. However, as the story progresses it i... ...it to show that kind of diversity. She probably wanted a release, to share her life, to get back at the Wier Cure, to show the injustice brought to women of the period and to probably just be creative. In finding reviews and biographies on Gilman one does not find too many bad words written on her. She is held as a very prestigious writer. As for the yellow wallpaper it really expands the minds and makes one have to sit back and analyze what was really going on.    Works Cited    Gilman, Charlotte Perkins. Why I Wrote "The Yellow Wallpaper"? http://www.cwrl.utexas.edu/ daniel/amlit/wallpaper/Whywrote.html    Korb, Rena. An Overview of "The Yellow Wallpgper," in Exploring Short Stories Literature Resource Center. Gale Research, 1998.    Stone, Les. Charlotte (Anna) Perkins (Stetson) Gilman. Contemporary A uthors Online. The Gale Group, 2000.

A business plan in transportation industry Essay

This demonstrates of a business plan in cargo and parcel transportation. This type of the business requires a lot of capital to venture into it. Firstly, transportation machinery such as motor vehicles, motorcycles, trains, aeroplanes and other equipment for transport are expensive to acquire. The business is client based. By client based, it means that, the business depends entirely on clients as customers for its survival. It is a great challenge to get clients for a new business. People would prefer to transport through people whom they have worked before with, and created a confidence on them that they are trusted people. The goal of the business is to ensure efficient, effective and customer satisfaction in transportation of client’s goods. Beginning a new business is faced by several challenges. It would require a rather market research before kicking off the business. Marketing research would mean employing professional in marketing to help the business venture strategi cally in the market. Employing professional in marketing to conduct a research is expensive for a business especially in its onset, hence, a great challenge to the start of the business (Barnhart, 119). Transportation of parcels and cargos is a business that cannot fail to take place at whatever cost it might mean. People will always keep on exchanging parcels, individuals and firms will always transact in cargos. The business of goods transportation will always be there as long as the world and people exist. The biggest challenge to this new business is how to get clients and source of the capital to start the business. In obtaining customers for this business, a rather marketing will be entailed. Such marketing may be contacted through advertising in television channels, personal approaches to different firms and holding business talks, billboard advertisement in city centres and all other related such marketing techniques. Not every other business would survive without suppliers. A business needs suppliers for its stock, equipment or machinery. Most, a company based on transportation and logistics would need a group of suppliers for it to survive. For an easy venture in the marke t, a business may opt to collaborate with another established business, to win a large market within a short time. In addition, collaborating with another business that latter business act, as complement to what it offers would mean strategic kick off a business. The business under discussion focuses on merging with one of the airlines company in the city to market itself. In the market there are several business offering the same services. These are actually the real to competitors to the business (Abrams, 18). There will always be competitors to a business; competitors may either be direct or indirect competitors. Direct competitors are those that offer same services and goods to those that another business is offering. On the other hand, indirect competitors are the ones that offer substitute products to those that another business is offering. The company will be well structure to counter with the competitors offering the same services in the market. Amongst the measures at hand to deal with competition are, relatively lower charges. This would help to attract more clients to the company. Increased clients means increased customers hence, increased output of this business. Relatively lower charges, is another strategy that will help to reduce the payback period or time of our business project. It is very essential for a business to have an environment that is conducive for its success. By engagement into corporate social responsibilities, the business will not ensure a health social environment for itself, but also act as way of promoting itself. Through involvement in corporate social responsibilities, the business creates a good shape to the people. It is also a way of publicizing a business. Both political and social environment ought to be maintained by the company. Our company will have at hand all proper and valid documentation for its legality. By having a business vision and mission, it will create a source of inspiration and centre of focus both to the employees and the shareholders to the company. The strategy to ensuring the business is a success is clear enough. Due to wise selection of the business to collaborate with, it will be easy for the business to start at high gear. Firstly, there is a ready market for to transport, this is because we are collaborating with an airline firm. Our company will execute all the transactions involving transport by the particular airline. We also need to have strategic location of our offices. All offices to the company are found within the city centre. This means that they are highly accessible to the customers. Simple and clear terms of the contract with the client will also quicken the conduct of the transactions of the company. These just but some of the strategies put in place to ensure that the company will be successful in its endeavours. Good and clear communication is another major element for a success of every business. Communication within the company shall be made as simple and clear as much as possible. Delegation of duties f rom directors to the casual worker will create a good leadership within the organization. Through delegation, a strong teamwork and network of employees will be maintained in the organization. This will ensure that the organization maintains good and clear communication skills. Good communication improves employees productivity, hence an increase in the general output of the company. It would be a great challenge of to get capital to start the business. The company has therefore to portray a good strategy for it to attract people to be shareholders or financiers. A good business plan can also be used to attract a capital borrowing in some government agencies that lend out finances to motivate entrepreneurship. The business strategy is clear and comprehensive enough to stand a chance to win capital borrowing from any investment bank or government policy. This is a strategy of selling the company’s idea to the potential investors (Karin, 313). In conclusion, people share so much in common, yet are so magnificently different. They think differently; they have different and sometimes competing values, motivations and objectives. It’s therefore very important to study the nature of the individuals so as to live peacefully with them to avoid confrontations with them. This same case applies to all business ventures. A business ought to conduct a viable market research before kicking off. Good market research would help a business recognise its strength and weaknesses. It will increase on strengths and try to minimise on the weakness, through this, a strong business idea would be realize that could see any business venture a success. References Abrams, Rhonda M. The Successful Business Plan: Secrets & Strategies. Palto Alto, Calif: Planning Shop,  2003. Print. Barnhart, Cynthia, and Gilbert Laporte. Transportation. Amsterdam: North Holland,  2007. Print. Jo?eveer, Karin. Sources of Capital Structure: Evidence from Transition Countries. Tallinn: Eesti Pank,  2006. Print. Source document

The Lit Of Western World - 1588 Words

Charles Taylor III Professor Travers Lit of Western World I November 24, 2015 Utopia Imagine a perfect world where no one has to work and where there is an abundant supply of resources. All the worlds’ goods are divided among all the people and the government takes care of everyone. All people are equal and can do whatever they please inside this perfect world. This perfect world is called Utopia. An island shaped like crescent moon two hundred miles across. The ends of the island meet at a point about eleven miles apart opening up to a calm bay. The entrance into Utopia has to two sides one side is a harbor where ships pass through in every direction to get in and out of Utopia. The other side is rocky and shallow. In the middle of the†¦show more content†¦The project Utopia was completely very fact because there were so many hands helping. A strange belief system had appeared among the people of Utopian. They believed that their new island that they created could be a perfect little society. The characteristics of this society include the following : Nobody has to work, unless he or she wanted to. There is an abundant supply of everything. There is no money, and everything is free, or all money is divided evenly among all people. All goods are divided equally among all people. People have as much time to pursue studies and arts as they want. Government would spend so much that the economy would run off the government spending. The Government would take care of everybody. All the people would be exactly equal. They would also have the privilege to do whatever they want to do. All religions have to be abolished. A perfect world like the one described cannot be reached by the Utopian people. There are several reasons why the Utopian people believe that this Utopian society can be reached. Many of them used the ancient Greek and Roman civilizations as examples of this, based upon what they have read in ancient literature, plays, and books on ancient culture. What the sources leave out is that all of the work was done by slaves. They believed that government spending would create wealth. They wanted the government to spend as much as it could, so there would be plenty of wealth to go around. They do not understand